[The last man on Earth, talking to a bust of Caesar.]
Robert Neville: Hi. Another day, another dollar. Miserable schmuck! SHUT UP! Why the hell can't you leave me alone? What day is it, anyway? Monday? Huh? The hell it is. It's Sunday. Sunday I always dress for dinner.
[The last man on Earth wrecks his car]
Robert Neville: There's never a cop around when you need one.
[Talking to his own image on a TV screen]
Robert Neville: Hi, Big Brother, how's your ass?
[Hearing the "Family" loudly holding a book-burning revel]
Robert Neville: At it again, I see? What will it be tonight? Museum of Science? Some library? Poor miserable bastards.
Little Girl: Are you God?
Lisa: Let's find out if he's even a doctor before we go promoting him, okay?
Dutch: I was a med school senior when they scratched the world. As a matter of fact, I was planning on applying to biowar labs for my post-doc, but, heh-heh, the next term never came.
Robert Neville: Now I'm sorry you didn't make it.
Lisa: Sorry the world didn't make it.
Lisa: Is there anything you can do, DOCTOR, I mean, seeing as how you've lost over 200 million patients?
Robert Neville: You know the old song? If you were the only girl in the world, and I was the only boy, well, okay, but until then, don't bother me? Well, I guess I'm the only boy...
[After Neville tosses her a submachine gun]
Lisa: What's this for?
Robert Neville: Comfort.
Robert Neville: And Speedy Bob Neville - his great legs churning goes speeding across the finish line with a three minute and fifty second mile. Go ahead, let's see some son-of-a-bitch beat that.
Robert Neville: Is this how it starts? A trip to the laughing academy? No you silly bastard, it starts with you asking yourself silly questions. Ok, let's get cleaned up.
Matthias: One creature, caught. Caught in a place he cannot stir from in the dark, alone, outnumbered hundreds to one, nothing to live for but his memories, nothing to live with but his gadgets, his cars, his guns, gimmicks... and yet the whole family can't bring him down from that, that...
Zachary: Honky paradise, brother?
Matthias: Forget the old ways, brother, all the old hatreds.
Lisa: Alright you son-of-a-bitch, you just hold tight. Up against the wall, you mother!
Robert Neville: My name's Robert.
Lisa: Your name's mud.
Lisa: Don't screw up. I know how to roll, but it's hard on the elbows. And if you just have to play James Bond, I'll bust your ass.
Lisa: It's OK, Tommy. This is the man... and I mean "The Man," but he's cool.
Zachary: Honky paradise, brother.
Dutch: You could save the world.
Lisa: Screw the world, save Ritchie.
Matthias: Definition of a scientist - A man who understands nothing until there was nothing left to understand.
Robert Neville: So, there is a little light in the forest after all.
Matthias: Take him to the little room... for questioning.